Handwritten Notes
Semester 3
BP301T. PHARMACEUTICAL ORGANIC CHEMISTRY —II (Theory)
UNIT I
• Benzene and its derivatives
A. Analytical, synthetic and other evidence in the derivation of the structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel's rule
B. Reactions of benzene - nitration, sulphonation, halogenation- reactivity, Friedel crafts alkylation- reactivity, limitations, Friedelcrafts acylation.
C. Substituents, the effect of substituents on reactivity and orientation of monosubstituted benzene compounds towards electrophilic substitution reaction
D. Structure and uses of DDT, Saccharin, BHC, and Chloramine
B. Reactions of benzene - nitration, sulphonation, halogenation- reactivity, Friedel crafts alkylation- reactivity, limitations, Friedelcrafts acylation.
C. Substituents, the effect of substituents on reactivity and orientation of monosubstituted benzene compounds towards electrophilic substitution reaction
D. Structure and uses of DDT, Saccharin, BHC, and Chloramine
UNIT II
• Phenols* - Acidity of phenols, the effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols
• Aromatic Amines* - Basicity of amines, the effect of substituents on basicity, and synthetic uses of aryl diazonium salts
• Aromatic Acids* —Acidity, effect of substituents on acidity, and important reactions of benzoic acid.
• Aromatic Amines* - Basicity of amines, the effect of substituents on basicity, and synthetic uses of aryl diazonium salts
• Aromatic Acids* —Acidity, effect of substituents on acidity, and important reactions of benzoic acid.
UNIT III
• Fats and Oils
a. Fatty acids— reactions.
b. Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.
c. Analytical constants Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value significance and principle involved in their determination.
a. Fatty acids— reactions.
b. Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.
c. Analytical constants Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value significance and principle involved in their determination.
UNIT IV
• Polynuclear hydrocarbons:
a. Synthesis, reactions
b. Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives
a. Synthesis, reactions
b. Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives
UNIT V
• Cyclo alkanes*
Stabilities Baeyer's strain theory, limitation of Bae yer's strain theory, Coulson and Moffitt's modification, Sachse Mohr's theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only
Recommended Books (Latest Editions)
1. Organic Chemistry by Morrison and Boyd
2. Organic Chemistry by I.L. Finar, Volume-I
3. Textbook of Organic Chemistry by B.S. Bahl & Arun Bahl.
4. Organic Chemistry by P.L.Soni
5. Practical Organic Chemistry by Mann and Saunders.
6. Vogel's textbook of Practical Organic Chemistry
7. Advanced Practical organic chemistry by N.K.Vishnoi.
2. Organic Chemistry by I.L. Finar, Volume-I
3. Textbook of Organic Chemistry by B.S. Bahl & Arun Bahl.
4. Organic Chemistry by P.L.Soni
5. Practical Organic Chemistry by Mann and Saunders.
6. Vogel's textbook of Practical Organic Chemistry
7. Advanced Practical organic chemistry by N.K.Vishnoi.
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