Handwritten Notes
Semester 3
BP302T. PHYSICAL PHARMACEUTICS-I (Theory)
UNIT-I
Solubility of drugs: Solubility expressions, mechanisms of solute-solvent interactions,
ideal solubility parameters, solvation & association, quantitative approach to the factors
influencing solubility of drugs, diffusion principles in biological systems.
Solubility of gas in liquids, the solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult's law, real solutions. Partially miscible liquids, Critical solution temperature, and applications. Distribution law, its limitations, and applications
UNIT-II
States of Matter and properties of matter: State of matter, changes in the state of matter, latent
heats, vapor pressure, sublimation critical point, eutectic mixtures, gases, aerosols
— inhalers, relative humidity, liquid complexes, liquid crystals, glassy states,
solid- crystalline, amorphous & polymorphism.
Physicochemical properties of drug molecules: Refractive index, optical rotation,
dielectric constant, dipole moment, dissociation constant, determinations and applications
UNIT-III
Surface and interfacial phenomenon: Liquid interface, surface & interfacial tensions, surface free energy, measurement of surface & interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface-active agents, HLB Scale, solubilization, detergency, adsorption at solid interface.
UNIT-IV
Complexation and protein binding: Introduction, Classification of Complexation,
Applications, methods of analysis, protein binding, Complexation, and drug action,
crystalline structures of complexes and thermodynamic treatment of stability constants.
UNIT-V
pH, buffers, and Isotonic solutions: Sorensen's pH scale, pH determination (electrometric and calorimetric), applications of buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems, buffered isotonic solutions.
Recommended Books: (Latest Editions)
1. Physical Pharmacy by Alfred Martin
2. Experimental Pharmaceutics by Eugene, Parott.
3. Tutorial Pharmacy by Cooper and Gunn.
4. Stocklosam J. Pharmaceutical Calculations, Lea &Febiger, Philadelphia.
5. Liberman H.A, Lachman C., Pharmaceutical Dosage forms, Tablets, Volume-1 to 3, MarcelDekkar Inc.
6. Liberman H.A, Lachman C, Pharmaceutical Dosage Forms. Disperse systems, volume 1, 2, 3. Marcel Dekkar Inc.
7. Physical Pharmaceutics by Ramasamy C and ManavalanR.
8. Laboratory Manual of Physical Pharmaceutics, C.V.S. Subramanyam, J. Thimma settee
9. Physical Pharmaceutics by C.V.S. Subramanyam
10. Test book of Physical Pharmacy, by Gaurav Jain & Roop K. Khar
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